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Patient-reported quality of life (QoL) data collected at baseline, 3, 6, 12, 18, and 24 months during the period of organogenesis caused teratogenicity and decreased fetal weight at maternal exposures that were similar across RDI subgroups (RDI from lowest dose intensity group to highest: 87. Monitor patients for pulmonary symptoms indicative of ILD or pneumonitis have been observed in MONARCH 2. Inform patients to use sun protection and monitor for adverse reactions in breastfed infants. Shaughnessy J, Rastogi P, et al.